M Roitman Lab, Department of Psychology, College of Liberal Arts & Sciences
I am interested in investigating how perturbations of physiological state impact motivated behavior and underlying dopamine neurotransmission. In the lab of Dr Mitchell Roitman, I study the influence of metabolic state, fluid balance and visceral illness on phasic dopamine signaling in response to both natural and drug rewards.
Cone JJ, Fortin SM, McHenry JA, Stuber GD, McCutcheon JE, Roitman MF. Physiological state gates acquisition and expression of mesolimbic reward prediction signals. PNAS. 2016 Feb 16;113(7):1943-8.
Fortin SM, Roitman MF. Central GLP-1 receptor activation mediates LiCl induced dopamine suppression in the nucleus accumbens. Neuropsychopharamacology. 2016 Feb;41(3):906-15.
Kanoski SE, Ong ZY, Fortin SM, Schlessinger ES, Grill HJ. Liraglutide, leptin and their combined effects on feeding: additive intake reduction through common intracellular signaling mechanism. Diabetes Obes Metab. 2015 Mar;17(3):285-93.
Fortin SM, Cone JJ, Ng-Evans S, McCutcheon JE, Roitman MF. Sampling phasic dopamine signaling with fast-scan cyclic voltammetry in awake, behaving rats. Curr Protoc Neurosci. 2015 Jan 5;70:7.25.1-7.25.20.
McCutcheon JE, Cone JJ, Sinon CG, Fortin SM, Kantak PA, Witten IB, Deisseroth K, Stuber GD, Roitman MF. Optical Suppression of drug-evoked phasic dopamine release. Front. Neural Circuits. 2014 Sept 17;8:114.
Kanoksi SE, Alhadeff AL, Fortin SM, Gilbert JR, Grill HJ. Leptin signaling in the medial nucleus tractus solitarius reduces food seeking and willingness to work for food. Neuropsychopharmacology. 2014 Feb;39(3):605-13.
Kanoski SE, Fortin SM, Ricks KM, Grill HJ. Ghrelin signaling in the ventral hippocampus stimulates learned and motivational aspects of feeding via PI3K-Akt signaling. Biol Psychiatry. 2013 May 1;73(9):915-23.
Kanoski, SE, Rupprecht L, Fortin SM, De Jonghe BC, Hayes MR. Body weight and food intake suppression by glucagon-like- peptide-1 receptor agonists, exendin-4 and liraglutide, may require nausea. Neuropharmacology. 2012 Apr;62(5-6):1916- 27.
Hayes MR, Kanoski SE, De Jonghe BC, Leichner TM, Alhadeff AL, Fortin SM, Arnold M, Langhans W, Grill HJ. The common hepatic branch of the vagus is not required to mediate the glycemic and food intake suppressive effects of glucagon-like- peptide-1. Am J Physiol Regul Integr Comp Physiol. 2011 Nov; 301(5):R1479-85.
Kanoski SE, Fortin SM, Arnold M, Grill HJ, Hayes MR. Peripheral and central GLP-1 receptor populations mediate the anorectic effects of peripherally administered GLP-1 receptor agonists, liraglutide and exendin-4. Endocrinology. 2011 Aug;152(8):3103-12.
Kanoski SE, Hayes MR, Greenwald HS, Fortin SM, Gianessi CA, Gilbert JR, Grill HJ. Hippocampal leptin signaling reduces food intake and modulates food-related memory processing. Neuropsychopharmacology. 2011 Aug;36(9):1859-70.
Fortin SM, Marshall SL, Jaeger EC, Greene PE, Brady LK, Isaac RE, Schrandt JC, Brooks DR, Lyczak R. The PAM-1 aminopeptidase regulates centrosome positioning to ensure anterior-posterior axis specification in one-cell C. elegans embryos. Dev Biol. 2010 Aug 15;344(2):992-1000.