Matthew Tobin

MD-PhD Candidate

Lazarov Lab, Department of Anatomy & Cell Biology, College of Medicine


Lab:  6040 COMRB

Phone: (312) 996-9530



Research Interests:

I study the interaction between inflammation and neurogenesis following ischemic stroke. More specifically, I am interested in the interplay between the response of microglia to stroke and how that impacts the ability for neural stem/progenitor cells to provide long-term functional recovery following stroke. I am also interested in the potential for bone marrow-derived mesenchymal stem cells to promote a pro-regenerative microglia phenotype and to promote the proliferation, differentiation, and long-term survival of neural stem/progenitor cells.



Tobin, M.K., Birk, D., Siemionow, K., Neckrysh, S., & Schizas, C. T1 pedicle subtraction osteotomy for the treatment of rigid cervical kyphotic deformity: clinical series of four patients and review of the literature. J. Neurosurg. Spine (in press, 2016).

Birk, D.M., Rangwala, S.D., Tobin, M.K., Krishna, P.H., Hahn, Y.S., & Nikas, D.C. Spontaneous resolution of spinal epidural hematoma resulting from domestic child abuse: Case report. Pediatr. Neurosurg., (in press, 2016).

Bonds, J.A., Kuttner-Hirshler, Y., Bartolotti, N., Tobin, M.K., Pizzi, M., Marr, R., & Lazarov, O. Presenilin-1 dependent neurogenesis regulates hippocampal learning and memory. PLoS One, 10 (2015) e0131266. (PMID: 26098332)

Birk, D.M., Tobin, M.K., Moss, H.E., Feinstein, E., Charbel, F.T., & Alaraj, A. Improvement in venous outflow following superior sagittal sinus decompression after a gunshot wound to the head: Case report. J. Neurosurg., 123 (2015) 81-85. (PMID: 25839927)

Alaraj, A., Tobin, M., Birk, D., & Aletich, V. Role of argatroban during neuro-interventional procedures in patients with heparin-induced thrombocytopenia. J. Neurointerv. Surg., 6 (2014) 630-632. (PMID: 24062254)

Tobin, M.K., Testai, F.D. Rare genetic causes of stroke. In: L.R. Caplan, J. Biller, M. Leary, A. Thomas, E. Lo, M. Yenari, & J. Zhang (eds), Primer on Cerebrovascualr Diseases, (2nd Ed.). Elsevier (in press, 2016).

Birk, D.M., Tobin, M.K., & Slavin, K.V. Neurosurgical options for control of chronic and malignant abdominal pain. In: L. Kapural (ed), Chronic Abdominal pain: An Evidence Based, Comprehensive Guide to Clinical Management. Springer (2014), pp. 239-244.

Alaraj, A., Tobin, M.K., Birk, D.M., & Charbel, F.T. Simulation for neurosurgery and neurosurgical procedures. In: A.I. Levine, S. DeMaria, A.D. Schwartz, & A.J. Sim (eds), The Comprehensive Textbook of Healthcare Simulation. Springer (2013) pp. 415-423.

Skeoch, G.D., Tobin, M.K., Khan, S., Linninger, A.A., & Mehta, A.I. Corticosteroid treatment for metastatic spinal cord compression: A review. Global Spine J. (in press, 2016).

Hobbs, J.G., Desai, B., Young, J.S., Polster, S.P., Tobin, M.K., Geraghty, J.R., Linninger A.A., Oyelese, A.A., Shin, J.H., Bydon, M., & Mehta, A.I. Intramedullary spinal cord tumors: A review and discussion of surgical rationale. World Spinal Column J., 7 (2016) 65-83.

Genev, I.K., Tobin, M.K., Zaidi, S., Khan, S., Amirouche, F., & Metha, A.I. Spinal compression fracture management: A review of current treatment strategies and possible future avenues. Global Spine J. (in press, 2016).

Tobin, M.K., Geraghty, J.R., Engelhard, H.H., Linninger, A.A., & Mehta, A.I. Intramedullary spinal cord tumors: A review of current and future treatment strategies. Neurosurg. Focus, 39 (2015) E14. (PMID: 26235012)

Tobin, M.K., Bonds, J.A., Minshall, R.D., Pelligrino, D.A., Testai, F.D., & Lazarov, O. Neurogenesis and inflammation following ischemic stroke: what is known and where we go from here. J. Cereb. Blood Flow Metab., 34 (2014) 1573-1584. (PMID: 25074747)

Antony, A.K., Rodby, K., Tobin, M.K., O’Connor, M.I., Pearl, R.K., DiPietro, L.A., Breidenbach, W.C., & Bartholomew, A.M. Composite tissue allotransplantation and dysregulation in tissue repair and regeneration: a role for mesenchymal stem cells. Front. Immunol., 4 (2013) article 188. (PMID: 23847625)

Alaraj, A., Charbel, F.T., Birk, D., Tobin, M., Luciano, C., Banerjee, P.P., Rizzi, S., Sorenson, J., Foley, K., Slavin, K., & Roitberg, B. Role of cranial and spinal virtual and augmented reality simulation using Immersive Touch modules in neurosurgical training. Neurosurg., 72 (suppl. 1) (2013) A115-A123. (PMID: 23254799)