Kevin Koster

KevinKosterHeadshotPhD Student

Laboratory: Uncommitted






Research Interests:

I am interested in understanding, on the synaptic, cellular and systems levels, the integrated homeostatic mechanisms that facilitate memory, cognition and complex behavior, as well as the dyshomeostatic events that ultimately lead to neurodegeneration, with a particular focus on Alzheimer’s disease.



Koster KP, Thomas R, Marottoli FM, Morris AWJ, Tai L. Epidermal growth factor prevents oligomeric amyloid-β induced angiogenesis deficits in vitro. J Cereb Blood Flow Metab. 2016 July [in press].

Koster KP, Smith C, Valencia-Olvera AC, Thatcher GR, Tai LM, LaDu MJ. Rexinoids as therapeutics for Alzheimer disease: Role of APOE. Curr Top Med Chem. 2016 Jun 16. [Epub ahead of print] PubMed PMID: 27320328.

Tai LM, Thomas R, Marottoli FM, Koster KP, Kanekiyo T, Morris AW, Bu G. The role of APOE in cerebrovascular dysfunction. Acta Neuropathol. 2016 May;131(5):709-23. doi: 10.1007/s00401-016-1547-z. Epub 2016 Feb 16. Review. PubMed PMID: 26884068; PubMed Central PMCID: PMC4837016.

Luo J, Lee SH, VandeVrede L, Qin Z, Ben Aissa M, Larson J, Teich AF, Arancio O, D’Souza Y, Elharram A, Koster K, Tai LM, LaDu MJ, Bennett BM, Thatcher GR. A multifunctional therapeutic approach to disease modification in multiple familial mouse models and a novel sporadic model of Alzheimer’s disease. Mol Neurodegener. 2016 Apr 29;11:35. doi: 10.1186/s13024-016-0103-6. Erratum in: Mol Neurodegener. 2016;11(1):40. PubMed PMID: 27129593; PubMed Central PMCID: PMC4850651.

Tai LM, Ghura S, Koster KP, Liakaite V, Maienschein-Cline M, Kanabar P, Collins N, Ben-Aissa M, Lei AZ, Bahroos N, Green SJ, Hendrickson B, Van Eldik LJ, LaDu MJ. APOE-modulated Aβ-induced neuroinflammation in Alzheimer’s disease: current landscape, novel data, and future perspective. J Neurochem. 2015 May;133(4):465-88. doi: 10.1111/jnc.13072. Epub 2015 Mar 18. Review. PubMed PMID: 25689586; PubMed Central PMCID: PMC4400246.

Liu DS, Pan XD, Zhang J, Shen H, Collins NC, Cole AM, Koster KP, Ben Aissa M, Dai XM, Zhou M, Tai LM, Zhu YG, LaDu M, Chen XC. APOE4 enhances age-dependent decline in cognitive function by down-regulating an NMDA receptor pathway in EFAD-Tg mice. Mol Neurodegener. 2015 Mar 5;10:7. doi: 10.1186/s13024-015-0002-2. PubMed PMID: 25871877; PubMed Central PMCID: PMC4391134.

Tai LM, Koster KP, Luo J, Lee SH, Wang YT, Collins NC, Ben Aissa M, Thatcher GR, LaDu MJ. Amyloid-β pathology and APOE genotype modulate retinoid X receptor agonist activity in vivo. J Biol Chem. 2014 Oct 31;289(44):30538-55. doi: 10.1074/jbc.M114.600833. Epub 2014 Sep 12. PubMed PMID: 25217640; PubMed Central PMCID: PMC4215234.