Loeb Lab, Department of Neurology & Rehabilitation, College of Medicine
I am interested in the cerebral vasculature and how trauma and inflammation play a role in seizure development and epileptogenesis. My project will focus on the role of the MAP kinase signaling pathway in epilepsy as well as the interplay between microglial cells and blood vessels in the brain and how these can contribute to spiking activity. Using an endovascular perforation model of subarachnoid hemorrhage coupled with long-term continuous EEG monitoring, I hope to understand how this injury plays a role in seizure development as well as encounter potential therapeutic options to prevent the long-term development of epilepsy.
Tobin MK*, Geraghty JR*, Engelhard HH, Linninger AA, and Mehta AI. Intramedullary spinal cord tumors: A review of current and future treatment strategies. Neurosurg Focus 39(2):E14, 2015. *co-first author
Hobbs JG, Desai B, Young JS, Polster SP, Tobin MK, Geraghty JR, Linninger AA, Oyelese AA, Shin JH, Bydon M, and Mehta AI. Intramedullary spinal cord tumors: A review and discussion of surgical rationale.. World Spinal Cord Journal 2:65-83, 2016.