PhD, University of Virginia
Professor and Head, Department of Psychology, College of Liberal Arts & Sciences
Office: 1066B BSB
Lab: B20 BSB
Web Site: Michael Ragozzino Departmental Page
I have a broad background in systems neuroscience that focuses on the neural basis of learning and memory. My research experience involves collaborating successfully with scientists and clinicians from various disciplines that has led to federally-funded research projects. My research program integrates neurochemical and neuropharmacological techniques with cognitive testing to understand basic neurochemical mechanisms that support cognitive flexibility. This work involves in vivo neurochemical techniques, e.g. in vivo microdialysis with HPLC and biosensor recordings. Both of these techniques have been successfully integrated with behavioral testing. The broader research program also focuses on the development of novel treatments to alleviate cognitive deficits in psychiatric disorders. Understanding how neurochemical signaling is altered in preclinical studies has led to neuropharmacological studies to determine how drugs that target major neuromodulatory systems, e.g. acetylcholine and serotonin, rescue learning and cognitive flexibility deficits.
Grospe GM, Baker PM, Ragozzino ME. Cognitive Flexibility Deficits Following 6-OHDA Lesions of the Rat Dorsomedial Striatum. Neuroscience. 2018 Mar 15;374:80-90.
Amodeo DA, Cuevas L, Dunn JT, Sweeney JA, Ragozzino ME. The adenosine A(2A) receptor agonist, CGS 21680, attenuates a probabilistic reversal learning deficit and elevated grooming behavior in BTBR mice. Autism Res. 2018 Feb;11(2):223-233.
Amodeo DA, Rivera E, Cook EH Jr, Sweeney JA, Ragozzino ME. 5HT(2A) receptor blockade in dorsomedial striatum reduces repetitive behaviors in BTBR mice. Genes Brain Behav. 2017 Mar;16(3):342-351.
D’Cruz AM, Mosconi MW, Ragozzino ME, Cook EH, Sweeney JA. Alterations in thefunctional neural circuitry supporting flexible choice behavior in autismspectrum disorders. Transl Psychiatry. 2016 Oct 11;6(10):e916.
Amodeo DA, Rivera E, Dunn JT, Ragozzino ME. M100907 attenuates elevated grooming behavior in the BTBR mouse. Behav Brain Res. 2016 Oct 15;313:67-70.