Mark Rasenick

DG10_03_28_081.JPGPhD, Wesleyan University

Distinguished Professor, Departments of Physiology & Biophysics and Psychiatry, College of Medicine

Director, Biomedical Neuroscience Training Program

Office: 2095 COMRB


Phone: (312) 996-6641


Web Site: Mark Rasenick Departmental Page


Research Interests: 

Dr. Rasenick’s work has focused on G protein signaling in the nervous system and the relationship of neurotransmitter activation to rapid modification of the cytoskeleton.  He has been particularly interested in how G proteins and the cytoskeleton work in concert to modify synaptic shape and to form a molecular basis for depression and the action of antidepressant drugs.  The most recent work from his group suggests the possibility of a simple blood test indicating depression and therapeutic response to antidepressant therapy.



Allen, J.A., Halverson-Tamboli, R.A., & Rasenick, M.M. Lipid raft microdomains and neurotransmitter signalling. Nature Rev Neurosci., 8 (2007) 128-140.

Czysz, A.H., Schappi, J.M., & Rasenick, M.M. Lateral diffusion of Gαs in the plasma membrane is decreased after chronic but not acute antidepressant treatment: role of lipid raft and non-raft membrane microdomains. Neuropsychopharmacol., 40 (2015) 766-773.

Sarma, T., Koutsouris, A., Yu, J.Z., Krbanjevic, A., Hope, T.J., & Rasenick, M.M. (2015) Activation of microtubule dynamics increases neuronal growth via the nerve growth factor (NGF)- and Gαs-mediated signaling pathways. J. Biol. Chem., 290 (2015) 10045-10056.

Erb, S.J, Schappi, J.M. & Rasenick, M.M. Antidepressants accumulate in lipid rafts independent of monoamine transporters to modulate redistribution of the G protein, Gαs. J. Biol. Chem. (in press, 2016).