Professor, Department of Physiology & Biophysics, College of Medicine
Co-Director: Master of Science in Medical Physiology program
Office: 2111 COMRB
Lab: 2148 COMRB
Web Site: Mark Brodie Departmental Page
My laboratory studies the electrophysiology of neurons of the ventral tegmental area in brain slices. We are interested in the actions of ethanol on the central nervous system, specifically on the dopaminergic neurons involved in reward and reinforcement. Specifically, we look at the effects of chronic and acute alcohol on VTA neurons and the epigenetic changes in response to chronic alcohol exposure.
Nimitvilai, S., Arora, D.S., McElvain, M.A. & Brodie, M.S. Suppression of Gq function using intrapipette delivery of shRNA during extracellular recording in the ventral tegmental area. Front. Cell. Neurosci., 7 (2013) article 7. (PMID: 23408114)
Arora, D.S., Nimitvilai, S., Teppen, T.L., McElvain, M.A., Sakharkar, A.J., You, C., Pandey, S.C., & Brodie, M.S. Hyposensitivity to gamma-aminobutyric Acid in the ventral tegmental area during alcohol withdrawal: Reversal by histone deacetylase inhibitors. Neuropsychopharmacol., 38 (2013) 1674-1684. (PMID: 23474591)
Nimitvilai, S., Herman, M., You, C., Arora, D.S., McElvain, M.A., Roberto, M. & Brodie, M.S. Dopamine D2 receptor desensitization by dopamine or corticotropin releasing factor in ventral tegmental area neurons is associated with increased glutamate release. Neuropharmacol., 82 (2014) 28-40. (PMID: 24657149)
Dutton, J.W., Chen, H., You, C., Brodie, M.S., & Lasek, A.W. Anaplastic lymphoma kinase (ALK) regulates binge-like drinking and dopamine receptor sensitivity in the ventral tegmental area, Addict. Biol. (in press, 2016). (PMID: 26752591)
Nimitvilai, S., You, C., Arora D.S., McElvain M.A., Vandegrift, B.A., Brodie, M.S., & Woodward, J.J. Differential effects of toluene and ethanol on dopaminergic neurons of the ventral tegmental area. Front. Neurosci. (in press, 2016).