Associate Professor of Physiology in Psychiatry, Department of Psychiatry, College of Medicine
Office: 529 SPH/PI
Lab: 277 SPH/PI
Phone: (312) 413-4572
Web Site: John Larson Departmental Page
Dr. Larson studies the cellular and molecular mechanisms of memory formation. Of primary interest is long-term potentiation (LTP), a form of synaptic plasticity thought to be responsible for memory storage in the mammalian forebrain. Research in the laboratory investigates the role of LTP in olfactory learning and memory in rodents with emphasis on mouse models of autism, mental retardation, and neurodegenerative diseases such as Alzheimer’s disease. Dr. Larson’s laboratory also studies neuronal specialization in the brains of naked mole-rats, in particular tolerance of brain neurons to extreme oxygen deprivation.
Gocel, J. & Larson, J., Synaptic NMDA receptor currents in anterior piriform cortex are reduced in the adult fragile X mouse. Neuroscience, 221 (2012) 170-181 (PMID: 22750206).
Gocel, J. & Larson, J. Evidence for loss of synaptic AMPA receptors in anterior piriform cortex of aged mice. Frontiers in Aging Neuroscience, 5 (2013) Article 39 (PMID: 23964238)
Larson, J., Drew, K.L., Folkow, L.P., Milton, S.L., & Park, T.J. No oxygen? No problem! Intrinsic brain tolerance to hypoxia in vertebrates. Journal of Experimental Biology, 217 (2014) 1024-1039 (PMID: 24671961).
Larson, J. Munkácsy, E. Theta-Burst LTP. Brain Research, 1621 (2015) 38-50 (PMID: 25452022).
Penz, O.K., Fuzik, J., Kurek, A.B., Romanov, R., Larson, J., Park, T.J., Harkany, T., & Keimpema, E. Protracted brain development in a rodent model of extreme longevity. Scientific Reports, 5 (2015) 11592 (PMCID: PMC4484490).