John S. Garvin Chair, Professor & Head
Department of Neurology and Rehabilitation
Office: 657 NPI
Phone: (312) 996-157
Website: Jeffrey Loeb’s website
We take forward and ‘reverse’ translational approaches to understand and develop novel treatments for neurological disorders. Forward translation comes from long-standing work on the gliotrophic factor neuregulin, includig how it is targeted, and the development of therapeutics to block it. With Dr. Fei Song we work on animal disease models of ALS, MS, and Alzheimer’s. Our reverse translational work has led to the development of a University-wide resource of rapidly acquired human tissues that are precisely linked to in vivo physiology, imaging, histology, genomics, proteomics, and metabolomics called the University of Illinois NeuroRepository with newly renovated interactive space on the 6th floor of the Neuropsychiatric institute. Our emphasis has been on human neocortical epilepsy, but is now expanded to ALS and brain tumors. The work in epilepsy has led to a new animal model and novel small molecule therapeutics to prevent epilepsy.
Dachet F., Bagla S., Karen-Aviram G, Morton A, Balan K, Saadat L, Valyi-Nagy T, Kupsky W., Song F, Dratz E, Loeb JA (2015) Predicting novel histopathological microlesions in human epileptic brain through transcriptional clustering Brain, 138:356-70
Wang J, Hmadcha A, Zakarian V, Song F, Loeb JA. (2015) Rapid transient isoform-specific neuregulin1 transcription in motor neurons is regulated by neurotrophic factors and axon-target interactions. Mol Cell Neurosci. 68:73-81.
Lipovich L, Dachet F, Bagla S, Balan K, Cai J, Jia H, Loeb JA, (2012) Activity-dependent human brain coding / non-coding gene regulatory networks, Genetics, 192(3):1133-1148.
Beaumont TL, Yao B, Shah A, Kapatos G, Loeb JA. (2012) Layer-Specific CREB target gene induction in human neocortical epilepsy, J Neurosci, 32(41):14389-14401.
Song F, Chiang P, Wang J, Ma Z, Ravits, J, Loeb JA. (2012) Abberant neuregulin 1 signaling in amyotrophic lateral sclerosis. J Neuropath Exp Neurol, 71:104-15.