Constance Jeffery

PhD, University of California, Berkeley

Associate Professor, Department of Biological Sciences, College of Liberal Arts & Sciences

Office: 4252 MBRB

Lab: 4260 MBRB

Phone: 312-996-3168


Web Site: Constance Jeffery Departmental Page


Research Interests:

The lab’s overall theme is the connection between the structures and functions of proteins. Current interests include moonlighting proteins, transmembrane receptors, mutations that cause disease, and inhibition of proteins involved in cancer and tuberculosis.  We use methods in bioinformatics, biochemistry, and biophysics, including X-ray crystallography.




Bhatt F, Patel V, Jeffery CJ. (2018) Open Conformation of the Escherichia coli Periplasmic Murein Tripeptide Binding Protein, MppA, at High Resolution. Biology (Basel). 7(2). pii: E30. doi: 10.3390/biology7020030. PMID: 29783769

Chang Chen, Shadi Zabad, Haipeng Liu, Wangfei Wang, C. J. Jeffery (2018) MoonProt 2.0: an expansion and update of the moonlighting proteins database.  Nucleic Acids Research, Volume 46, Issue D1, 4 January 2018, Pages D640–D644,

C. J. Jeffery. (2018) Protein moonlighting: What is it, and why is it important. Philosophical Transactions of the Royal Society B.  Jan 19;373(1738). pii: 20160523. doi: 10.1098/rstb.2016.0523. PMID:29203708

  1. J. Jeffery (2018) Intracellular proteins moonlighting as bacterial adhesion factors. AIMS Microbiology. 4(2): 362–376. DOI: 10.3934/microbiol.2018.2.362