Amy Lasek

PhD, Cornell UniversityAmy Lasek Nov 21 2013

Assistant Professor, Department of Psychiatry, College of Medicine

Office: 466 SPH/PI

Lab: 375 SPH/PI

Phone: 312-355-1593

email: alasek@psych.uic.edu

Web Site: Amy Lasek Departmental Page

 

Research Interests:

The goal of the research performed in Dr. Lasek’s laboratory is to understand the molecular and cellular underpinnings of alcohol and substance use disorders. To this end, we use molecular genetic and pharmacological techniques in the mouse to examine the effect of gene knockdown or knockout on behavioral responses to alcohol and cocaine. We recently found that small-molecule inhibitors targeting the ALK receptor tyrosine kinase reduce binge-like ethanol consumption, suggesting that use of these inhibitors may be a novel therapeutic strategy to reduce alcohol drinking in humans. My laboratory is also interested in studying sex differences in alcohol and drug abuse. We are currently investigating the function of estradiol and its receptors in the brain to understand the molecular mechanisms and neural circuitry through which estradiol exerts enhanced responses to cocaine and alcohol in females.

 

Publications:

Dutton, J.W., Chen, H., You, C., Brodie, M.S. & Lasek, A.W. Anaplastic lymphoma kinase (ALK) regulates binge-like drinking and dopamine receptor sensitivity in the ventral tegmental area. Addict. Biol., (in press, 2016) (PMCID: PMC4940304)

Chen, H., He, D., & Lasek, A.W. (2015) Repeated binge drinking increases perineuronal nets in the insular cortex. Alcohol. Clin. Exp. Res., 39 (2015) 1930-1938. (PMCID: PMC4592458)

He, D., Chen, H., Muramatsu, H., & Lasek, A.W. Ethanol activates midkine and anaplastic lymphoma kinase signaling in neuroblastoma cells and in the brain. J. Neurochem., 135 (2015) 508-521. (PMCID: PMC4618084)

Savarese, A., Zou, M.E., Kharazia, V., Maiya, R, & Lasek, A.W. Increased behavioral responses to ethanol in Lmo3 knockout mice. Genes Brain Behav., 3 (2014) 777-783. (PMCID: PMC4442799)

Hilderbrand, E.R. & Lasek, A.W. Sex differences in cocaine conditioned place preference in C57BL/6J mice. NeuroReport, 25 (2014) 105-109. (PMID: 24145777)