Assistant Professor, Department of Anatomy & Cell Biology, College of Medicine
Office: 6051 COMRB
Lab: 6068 COMRB
Phone: (312) 996-4954
Web Site: Akira Yoshii Departmental Page
My research focuses on activity-dependent synapse formation and connectivity of cortical circuits during development. I combine molecular, electrophysiological and imaging techniques to examine glutamatergic and GABAergic synapses, and study developmental plasticity in the mouse visual cortex. Currently, I study palmitoylation, which is critical for trafficking and functions of many synaptic proteins. I also work on tuberous sclerosis complex, a genetic disease caused by mutations of a protein that regulates mTOR pathway.
Yoshii, A. & Constantine-Paton, M. Postsynaptic localization of PSD-95 is regulated by all three pathways downstream of TrkB signaling. Front. Synaptic Neurosci., 6 (2014) 6.
Yoshii, A., Zhao, J.P., Pandian, S., van Zundert, B., & Constantine-Paton, M. MyosinVa mutant mouse with disruptions in glutamate synaptic development and mature plasticity in visual cortex. J. Neurosci., 33 (2013) 8472-8482.
Yoshii, A., Murata, Y., Kim, J., Zhang, C., Shokat, K. M., & Constantine-Paton, M. (2011). TrkB and protein kinase Mzeta regulate synaptic localization of PSD-95 in developing cortex. J. Neurosci., 31 (2011) 11894-11904.
Yoshii, A. & Constantine-Paton, M. BDNF induces transport of PSD-95 to dendrites through PI3K-AKT signaling after NMDA receptor activation. Nature Neurosci., 10 (2007) 702-711.
Yoshii, A., Sheng, M.H., & Constantine-Paton, M. Eye opening induces a rapid dendritic localization of PSD-95 in central visual neurons. PNAS, 100 (2003) 1334-1339.