David Braun

DavidBraunHeadshotPhD (2016), Advisor: D. Feinstein, Department of Anesthesiology

Dissertation: “Damage to the Locus Coeruleus in Alzheimer’s Disease: Potential Causes and Therapeutic Targets”


Current Position: Postdoctoral Fellow, Laboratory of Linda Van Eldik, Sanders-Brown Center on Aging, University of Kentucky



Research Interests:

I’m interested in the role of the locus coeruleus/noradrenaline system in restricting Alzheimer’s disease pathology, and the preclinical development of therapeutics targeting this system.



Feinstein, D. L., Akpa, B. S., Ayee, M. A., Boullerne, A. I., Braun, D., Brodsky, S. V., Gidalevitz, D., Hauck, Z., Kalinin, S., Kowal, K., Kuzmenko, I., Lis, K., Marangoni, N., Martynowycz, M. W., Rubinstein, I., van Breemen, R., Ware, K., Weinberg, G. The emerging threat of superwarfarins: history, detection, mechanisms, and countermeasures. Annals of the New York Academy of Sciences. Epub ahead of print.

Marangoni, N. M., Braun, D., Situ, A., Moyano, A. L., Kalinin, S., Polak, P. E., Givogri, M., Feinstein, D. L. 2016.Differential effects on glial activation by a direct versus an indirect thrombin inhibitor. Journal of Neuroimmunology, DOI: http://dx.doi.org/10.1016/j.jneuroim.2016.05.018.

Marangoni, N. M., Martynowycz, M. W., Kuzmenko, I., Braun, D., Polak, P. E., Weinberg, G., Rubinstein, I., Gidalevitz, D., Feinstein, D. L. 2016. Membrane cholesterol modulates superwarfarin toxicity. Biophysical Journal, 110(8), 1777-88.

Feinstein, D. L., Kalinin, S., Braun, D. 2015. Causes, consequences and cures for neuroinflammation mediated via the Locus coeruleus: Noradrenergic signaling system. Journal of Neurochemistry, DOI: 10.1111/jnc.13447.

Braun, D., Madrigal, J. L., Feinstein, D. L. 2014. Noradrenergic regulation of glial activation: molecular mechanisms and therapeutic implications. Current Neuropharmacology, 12(4), 342-352.

Boullerne, A. I., Polak, P. E., Braun, D., Sharp, A., Pellegrino, D., Feinstein, D. L. 2014. Effects of peptide fraction and counter ion on the development of clinical signs in experimental autoimmune encephalomyelitis. Journal of Neurochemistry,129(4), 696-703.

Ghods, A. J., Glick, R., Braun, D., Feinstein, D. 2013. Beneficial actions of the anti-inflammatory dimethyl fumarate in glioblastomas. 2013. Surgical Neurology International, 4(1), 160-165.

Kalinin, S., Polak, P. E., Lin, S. X., Braun, D., Guizzetti, M., Zhang, X., Rubinstein, I. Feinstein, D. L., 2013.Dimethyl fumarate regulates histone deacetylase expression in astrocytes. Journal of Neuroimmunology, 263(1-2), 13-19.

Polak, P. E., Kalinin, S., Braun, D., Sharp, A., Lin S.X., Feinstein D.L., 2011. The vincamine derivative vindeburnol provides benefit in a mouse model of multiple sclerosis: effects on the Locus coeruleus. Journal of Neurochemistry, 121(2), 206-216.